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BioXCell热销产品--RecombiMAb anti-mouse Ly6G

2023-09-01
浏览次数: 95

BioXCell热销产品--RecombiMAb anti-mouse Ly6G

 

产品描述:

1A8-CP129单克隆抗体是原始1A8单克隆抗体的重组嵌合型抗体。可变结构域序列与原始1A8相同,但是恒定区序列已经从大鼠IgG2a变为小鼠IgG2a。1A8-CP129单克隆抗体像原始克隆号的大鼠IgG2a抗体一样,不包含Fc突变。

 

1A8-CP129单克隆抗体与小鼠Ly6G反应。Ly6G分子量为21-25kDa,是GPI锚定的细胞表面蛋白Ly-6超家族的成员,在细胞信号传导和细胞粘附中发挥作用。Ly6G在发育过程中由骨髓谱系中的细胞(包括单核细胞、巨噬细胞、粒细胞和嗜中性粒细胞)差异表达。单核细胞通常在发育过程中瞬时表达Ly6G,而成熟的粒细胞和外周嗜中性粒细胞持续表达,使Ly6G成为这些细胞群体的表面标志物。与BioXcell RB6-8C5单克隆抗体不同,1A8-CP129单克隆抗体与小鼠Ly6G特异性反应,而与Ly6C没有交叉反应性的报道。

BioXCell热销产品--RecombiMAb anti-mouse Ly6G

 


产品详情:

产品名称

RecombiMAb anti-mouse Ly6G

产品货号

CP129

产品规格

1/5/25/50/100mg

反应种属

Mouse

克隆号

1A8-CP129

同种型

Mouse IgG2a(switched from rat IgG2a)

免疫原

EL4J cells transfected with Ly6G

实验应用

in vivo neutrophil depletion*

in vivo MDSC depletion*

Immunofluorescence*

Immunohistochemistry (paraffin)*

Immunohistochemistry (frozen)*

Flow cytometry*

*Reported for the original rat IgG2a 1A8 antibody

产品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

纯度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

无菌处理

0.2 µm filtration

纯化方式

Protein G

分子量

150 kDa

小鼠病原检测

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存条件

抗体原液保存在4°C,不能冷冻保存。

推荐同型对照

InVivoPlus mouse IgG2a isotype control, unknown specificity(货号BP0085)

推荐抗体稀释液

InVivoPure pH 7.0 Dilution Buffer(货号IP0070)

 

该产品自上市已被多篇SCI文献引用,品质有保证,以下是部分已发表的文献引用:

应用

文章

体内中性粒细胞耗竭

(in vivo neutrophil depletion)

1. Davis, R. W. t., et al. (2018). 'Luminol Chemiluminescence Reports Photodynamic 

Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic 

Efficacy' Photochem Photobiol .

2. Moynihan, K. D., et al. (2016). 'Eradication of large established tumors in mice by 

combination immunotherapy that engages innate and adaptive immune responses' Nat Med. 

doi : 10.1038/nm.4200.

3. Conde, P., et al. (2015). 'DC-SIGN(+) Macrophages Control the Induction of Transplantation 

Tolerance' Immunity 42(6): 1143-1158.

4. Griseri, T., et al. (2015). 'Granulocyte Macrophage Colony-Stimulating Factor-Activated 

Eosinophils Promote Interleukin-23 Driven Chronic Colitis' Immunity 43(1): 187-199.

5. Yamada, D. H., et al. (2015). 'Suppression of Fcgamma-receptor-mediated antibody 

effector function during persistent viral infection' Immunity 42(2): 379-390. 

体内中性粒细胞耗竭、流式细胞术、

免疫组化石蜡切片(in vivo neutrophil 

depletion, Flow Cytometry, 

Immunohistochemistry (paraffin))

Coffelt, S. B., et al. (2015). 'IL-17-producing gammadelta T cells and neutrophils conspire 

to promote breast cancer metastasis' Nature 522(7556): 345-348.

体内中性粒细胞耗竭、流式细胞术、

免疫组化石蜡切片、免疫组化冰冻切片

(in vivo neutrophil depletion, Flow 

Cytometry, Immunohistochemistry 

(paraffin), Immunohistochemistry (frozen)

Finisguerra, V., et al. (2015). 'MET is required for the recruitment of anti-tumoural 

neutrophils' Nature 522(7556): 349-353.

体内中性粒细胞耗竭、流式细胞术

(in vivo neutrophil depletion, 

Flow Cytometry)

1.Moser, E. K., et al. (2014). 'Late engagement of CD86 after influenza virus 

clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner' 

PLoS Pathog 10(8): e1004315.

2. Chen, K. W., et al. (2014). 'The neutrophil NLRC4 inflammasome selectively 

promotes IL-1beta maturation without pyroptosis during acute Salmonella 

challenge' Cell Rep 8(2): 570-582.

3. Garraud, K., et al. (2012). 'Differential role of the interleukin-17 axis and 

neutrophils in resolution of inhalational anthrax' Infect Immun 80(1): 131-142.

体内骨髓来源抑制细胞耗竭

(in vivo MDSC depletion)

Deng, L., et al. (2014). 'Irradiation and anti-PD-L1 treatment synergistically 

promote antitumor immunity in mice' J Clin Invest 124(2): 687-695.

体内中性粒细胞耗竭、

免疫荧光(in vivo neutrophil 

depletion, Immunofluorescence)

Edelson, B. T., et al. (2011). 'CD8alpha(+) dendritic cells are an obligate 

cellular entry point for productive infection by Listeria monocytogenes' 

Immunity 35(2): 236-248.

 

 


BioXCell热销产品--RecombiMAb anti-mouse Ly6G

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